Document Detail


Memory, navigation and theta rhythm in the hippocampal-entorhinal system.
MedLine Citation:
PMID:  23354386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Theories on the functions of the hippocampal system are based largely on two fundamental discoveries: the amnestic consequences of removing the hippocampus and associated structures in the famous patient H.M. and the observation that spiking activity of hippocampal neurons is associated with the spatial position of the rat. In the footsteps of these discoveries, many attempts were made to reconcile these seemingly disparate functions. Here we propose that mechanisms of memory and planning have evolved from mechanisms of navigation in the physical world and hypothesize that the neuronal algorithms underlying navigation in real and mental space are fundamentally the same. We review experimental data in support of this hypothesis and discuss how specific firing patterns and oscillatory dynamics in the entorhinal cortex and hippocampus can support both navigation and memory.
Authors:
György Buzsáki; Edvard I Moser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-28
Journal Detail:
Title:  Nature neuroscience     Volume:  16     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-03-22     Revised Date:  2014-07-04    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  130-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Entorhinal Cortex / physiology*
Hippocampus / physiology*
Humans
Memory / physiology*
Models, Neurological
Neural Pathways / physiology
Neurons / physiology
Space Perception / physiology*
Spatial Behavior / physiology*
Theta Rhythm / physiology*
Grant Support
ID/Acronym/Agency:
MH54671/MH/NIMH NIH HHS; NS 074015/NS/NINDS NIH HHS; NS34994/NS/NINDS NIH HHS; R01 MH054671/MH/NIMH NIH HHS; R01 NS034994/NS/NINDS NIH HHS
Comments/Corrections

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