Document Detail


Memory in individuals with mild cognitive impairment in relation to APOE and CSF Abeta42.
MedLine Citation:
PMID:  20338079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The epsilon4 allele of the apolipoprotein E (APOE) gene and low levels of cerebrospinal fluid (CSF) amyloid beta-proteins 42 (Abeta) have previously been associated with increased risk of cognitive decline in old age. In this study we examine the interaction of these markers with episodic memory in a sample identified as having mild cognitive impairment (MCI). METHODS: The sample (N = 149) was drawn from the Gothenburg MCI study and measured according to three free recall tests on three occasions spanning over four years. Second-order Latent Curve Models (LCM) were fitted to the data. RESULTS: Analyses accounting for age, gender, education, APOE, Abeta42, and interaction between APOE and Abeta42 revealed that the epsilon4 allele was significantly associated with level of memory performance in the presence of low Abeta42 values (< or = 452 ng/L). Associations between memory performance and Abeta42 were significant among the epsilon4 carriers but not among the non-carriers. The Abeta42 marker was, however, significantly associated with changes in memory over the study time period in the total sample. CONCLUSION: The findings support the hypothesis of an interactive effect of APOE and Abeta42 for memory decline in MCI patients.
Authors:
Valgeir Thorvaldsson; Arto Nordlund; Ivar Reinvang; Kaj Blennow; Henrik Zetterberg; Anders Wallin; Boo Johansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-26
Journal Detail:
Title:  International psychogeriatrics / IPA     Volume:  22     ISSN:  1741-203X     ISO Abbreviation:  Int Psychogeriatr     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007918     Medline TA:  Int Psychogeriatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  598-606     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Gothenburg, SE-405 30 Gothenburg, Sweden. Valgeir.Thorvaldsson@psy.gu.se
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MeSH Terms
Descriptor/Qualifier:
Amyloid beta-Protein / cerebrospinal fluid*,  genetics*
Apolipoprotein E4 / cerebrospinal fluid*,  genetics*
Chromosomes, Human, Pair 19 / genetics
Cognition Disorders / diagnosis,  epidemiology*,  genetics*
Female
Humans
Male
Memory Disorders / epidemiology*,  genetics*
Middle Aged
Neuropsychological Tests
Peptide Fragments / cerebrospinal fluid*,  genetics*
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Apolipoprotein E4; 0/Peptide Fragments; 0/amyloid beta-protein (1-42)

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