| Memory deficits and retrieval processes in ALS. | |
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MedLine Citation:
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PMID: 12752394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Subtle neuropsychological deficits have been described in patients affected by amyotrophic lateral sclerosis (ALS) without dementia. Overall, selective impairment in memory function has been reported, but the source of memory impairment in ALS has yet to be defined. We performed neuropsychological screening in 20 ALS patients. Semantic encoding and post-encoding cue effects on the retrieval of word lists were investigated in the ALS patients and normal controls. Severity of memory impairment was correlated to cerebral blood perfusion detected by single photon emission computed tomography (SPECT). ALS patients showed moderate impairments in frontal and memory tests. Short-term memory was normal, while serial position retrieval of word lists with normal recency effect but poor primacy effect showed long-term memory deficit. ALS patients performed better in cued encoding than in cued post-encoding recall condition. In the cued post-encoding condition, the primacy effect in word list recall improved significantly in controls, but not in ALS patients, as compared with both the free recall and cued encoding conditions. SPECT hypoperfusion was observed in frontal and temporal areas in ALS patients. ALS patients showed a long-term memory deficit which did not improve in cued post-encoding condition as it does for controls. We hypothesize abnormal retrieval processes related to frontal lobe dysfunction which entails difficulties in generating stable long-memory traces at encoding. |
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Authors:
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M C Mantovan; L Baggio; G Dalla Barba; P Smith; E Pegoraro; G Soraru'; P Bonometto; C Angelini |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 10 ISSN: 1351-5101 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-19 Completed Date: 2003-06-16 Revised Date: 2012-05-09 |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 221-7 Citation Subset: IM |
Affiliation:
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Department of Neurological and Psychiatric Sciences, University of Padua, Padua, Italy. mcmantovan@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amyotrophic Lateral Sclerosis / complications, physiopathology* Apolipoproteins E / analysis Cues Female Humans Male Memory Disorders / etiology, physiopathology* Mental Recall / physiology* Middle Aged Neurologic Examination Neuropsychological Tests Semantics Tomography, Emission-Computed, Single-Photon / instrumentation Wechsler Scales / statistics & numerical data |
| Grant Support | |
ID/Acronym/Agency:
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GTF02009//Telethon |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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