| Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. | |
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MedLine Citation:
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PMID: 19305395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effective immunity is dependent on long-surviving memory T cells. Various memory subsets make distinct contributions to immune protection, especially in peripheral infection. It has been suggested that T cells in nonlymphoid tissues are important during local infection, although their relationship with populations in the circulation remains poorly defined. Here we describe a unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia. These T cells were in disequilibrium with the circulating lymphocyte pool and controlled new infection with this virus. Thus, these cells represent an example of tissue-resident memory T cells that can provide protective immunity at points of pathogen entry. |
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Authors:
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Thomas Gebhardt; Linda M Wakim; Liv Eidsmo; Patrick C Reading; William R Heath; Francis R Carbone |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-22 |
Journal Detail:
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Title: Nature immunology Volume: 10 ISSN: 1529-2916 ISO Abbreviation: Nat. Immunol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-21 Completed Date: 2009-06-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100941354 Medline TA: Nat Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 524-30 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, The University of Melbourne, Melbourne Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adoptive Transfer Animals CD8-Positive T-Lymphocytes / immunology* Chemotaxis, Leukocyte / immunology Flow Cytometry Ganglia, Sensory / cytology, immunology*, virology Herpes Simplex / immunology* Immunohistochemistry Immunologic Memory* Lymphocyte Activation / immunology Mice Mice, Transgenic Simplexvirus / immunology Skin / cytology, immunology*, virology T-Lymphocyte Subsets / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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//Howard Hughes Medical Institute |
| Comments/Corrections | |
Comment In:
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Nat Immunol. 2009 May;10(5):451-3
[PMID:
19381136
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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