| Membranous glomerulonephritis and nephrosis post factor IX infusions in hemophilia B. | |
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MedLine Citation:
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PMID: 9811389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Children with hemophilia B who receive exogenous factor IX infusions may rarely develop inhibitors to the exogenous factor IX and require desensitization. Nephrotic syndrome has recently been described in some of these children. We report the renal clinicopathological findings in a child with severe factor IX deficiency, requiring induction of an immune tolerance protocol, who developed nephrotic syndrome. Renal biopsy revealed peripheral capillary wall thickening and a spike appearance consistent with membranous glomerulonephritis. Electron microscopy showed prominent deposits throughout the thickness of the basement membrane. Factor IX dose reduction was accompanied by reversal of the child's nephrotic syndrome without relapses. |
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Authors:
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V R Dharnidharka; C Takemoto; B M Ewenstein; S Rosen; H W Harris |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 12 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-02-11 Completed Date: 1999-02-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 654-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Factor IX / adverse effects*, therapeutic use Glomerulonephritis, Membranous / etiology*, pathology Hemophilia B / therapy* Humans Infant Kidney / pathology, ultrastructure Male Microscopy, Electron Nephrotic Syndrome / etiology*, pathology |
| Chemical | |
Reg. No./Substance:
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9001-28-9/Factor IX |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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