| Membranoproliferative glomerulonephritis. | |
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MedLine Citation:
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PMID: 19908070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Membranoproliferative glomerulonephritis is an uncommon kidney disorder characterized by mesangial cell proliferation and structural changes in glomerular capillary walls. It can be subdivided into idiopathic and secondary forms, which are differentially diagnosed by a review of clinical features, laboratory data, and renal histopathology. Three types-I, II, and III-have been defined by pathologic features. All three types are associated with hypocomplementemia, but they manifest somewhat different mechanisms of complement activation. Type II, also known as "dense deposit disease", is associated with the presence of C3-nephritic factor. Membranoproliferative glomerulonephritis primarily affects children and young adults, with patients presenting with nephrotic or nephritic syndrome or with asymptomatic renal disease. This type of glomerulonephritis often progresses slowly to end-stage renal disease, and it tends to recur after renal transplantation, especially type II. The efficacy of various forms of treatment remains controversial; however, long-term steroid treatment seems to be effective in children with nephrotic-range proteinuria. Improvement in renal outcomes largely relies on the evaluation of more selective agents in carefully controlled studies. |
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Authors:
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Bassam Alchi; David Jayne |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-11-12 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 25 ISSN: 1432-198X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-06-18 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 1409-18 Citation Subset: IM |
Affiliation:
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Renal Unit, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Complement Activation Complement C3 Nephritic Factor Glomerulonephritis / pathology Glomerulonephritis, Membranoproliferative / diagnosis, drug therapy*, pathology* Humans Kidney / pathology Kidney Diseases / pathology Kidney Failure, Chronic / pathology Kidney Glomerulus / pathology Kidney Transplantation |
| Chemical | |
Reg. No./Substance:
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0/Complement C3 Nephritic Factor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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