Document Detail


Membranoproliferative glomerulonephritis in a girl and her mother.
MedLine Citation:
PMID:  18641916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A girl and her mother were diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I. Microscopic hematuria and proteinuria presented at 9 years of age in the mother and at 14 years in the daughter. Both had persistent hypocomplementemia and were treated with steroids. When the mother was 40 years old, proteinuria was still continuing and creatinine clearance was 64.4 ml/min per 1.73 m(2). When the daughter was 15 years old, microscopic hematuria was still continuing. To our knowledge, familial cases of MPGN in two generations have not been reported in Japan.
Authors:
Osamu Motoyama; Ken Sakai; Yasushi Ohashi; Sonoo Mizuiri; Tsutomu Hatori; Kikuo Iitaka; Yasushi Koitabashi
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-07-19
Journal Detail:
Title:  Clinical and experimental nephrology     Volume:  13     ISSN:  1342-1751     ISO Abbreviation:  Clin. Exp. Nephrol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709923     Medline TA:  Clin Exp Nephrol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Toho University Medical Center, Sakura Hospital, 564-1 Shimoshizu, Sakura, Chiba, Japan. motoyan@basil.ocn.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biopsy
Child
Complement System Proteins / immunology
Creatinine / blood
Female
Genetic Predisposition to Disease
Glomerulonephritis, Membranoproliferative / complications,  diagnosis*,  drug therapy,  genetics,  immunology
Hematuria / etiology
Humans
Kidney Glomerulus / immunology,  metabolism,  pathology*
Pedigree
Pregnancy
Proteinuria / etiology
Steroids / therapeutic use
Chemical
Reg. No./Substance:
0/Steroids; 60-27-5/Creatinine; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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