Document Detail


Membrane tubulovesicular extensions (cytonemes): secretory and adhesive cellular organelles.
MedLine Citation:
PMID:  23287580     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this review, we summarized data on the formation and structure of the long and highly adhesive membrane tubulovesicular extensions (TVEs, membrane tethers or cytonemes) observed in human neutrophils and other mammalian cells, protozoan parasites and bacteria. We determined that TVEs are membrane protrusions characterized by a uniform diameter (130-250 nm for eukaryotic cells and 60-90 nm for bacteria) along the entire length, an outstanding length and high rate of development and a high degree of flexibility and capacity for shedding from the cells. This review represents TVEs as protrusions of the cellular secretory process, serving as intercellular adhesive organelles in eukaryotic cells and bacteria. An analysis of the physical and chemical approaches to induce TVEs formation revealed that disrupting the actin cytoskeleton and inhibiting glucose metabolism or vacuolar-type ATPase induces TVE formation in eukaryotic cells. Nitric oxide is represented as a physiological regulator of TVE formation.
Authors:
Svetlana I Galkina; Natalia V Fedorova; Vladimir I Stadnichuk; Galina F Sud'ina
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-03
Journal Detail:
Title:  Cell adhesion & migration     Volume:  7     ISSN:  1933-6926     ISO Abbreviation:  Cell Adh Migr     Publication Date:    2013 Mar-Apr
Date Detail:
Created Date:  2013-03-07     Completed Date:  2013-08-19     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101469464     Medline TA:  Cell Adh Migr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-86     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Actin Cytoskeleton / physiology
Animals
Bacteria / metabolism,  ultrastructure*
Cell Adhesion
Cell Communication
Cell Surface Extensions / physiology*,  ultrastructure*
Eukaryota / physiology*,  ultrastructure*
Fibronectins
Humans
Neutrophils / metabolism,  physiology*,  ultrastructure*
Chemical
Reg. No./Substance:
0/Fibronectins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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