| Membrane transport of long-chain fatty acids: evidence for a facilitated process. | |
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MedLine Citation:
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PMID: 9831619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In mammalian cells, membrane uptake of long-chain fatty acids is mediated by two separate components; a passive component that is a linear function of the concentration of free fatty acid in the extracellular medium and a saturable component that exhibits the characteristics of a protein-facilitated process. This review summarizes the body of work that has accumulated related to the mechanism of fatty acid transport. Evidence in support of a facilitated uptake process is presented with relation to the different cell types or membrane systems where it was collected. The evidence includes saturation kinetics, competition between different substrates, and sensitivity to a variety of inhibitors. Recent knowledge related to membrane proteins thought to be implicated in the uptake process is reviewed. Factors that may modulate uptake or alter the relative contribution of passive versus facilitated components are briefly discussed. These include the molar ratio of fatty acid to its physiological carrier, plasma albumin and the metabolic or hormonal milieu. |
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Authors:
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N Abumrad; C Harmon; A Ibrahimi |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of lipid research Volume: 39 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-02-11 Completed Date: 1999-02-11 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2309-18 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, State University of New York, Stony Brook, NY 11794, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / physiology Carrier Proteins / physiology Cell Membrane / metabolism Fatty Acid Transport Proteins Fatty Acids / pharmacokinetics* Humans Membrane Lipids / metabolism* Membrane Proteins / physiology Membrane Transport Proteins* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Fatty Acid Transport Proteins; 0/Fatty Acids; 0/Membrane Lipids; 0/Membrane Proteins; 0/Membrane Transport Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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