| Membrane structure-function relationships in cell-mediated cytolysis. I. Effect of exogenously incorporated fatty acids on effector cell function in cell-mediated cytolysis. | |
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MedLine Citation:
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PMID: 6446577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fatty acid composition of the membrane phospholipids of CTL memory cells restimulated with Con A can be altered significantly when selected exogenous fatty acids are present during the restimulation culture period. Such alterations also lead to significant changes in the subsequent cytolytic capacity of the regenerated CTL. Unsaturated fatty acids increase cytotoxicity, whereas saturated fatty acids lead to decreased cytotoxic function. The kinetics of the fatty acid effect on CTL function is the same as the kinetics of fatty acid incorporation into membrane phospholipids, suggesting that alteration of cytotoxicity results from altering membrane phospholipid fatty acid composition. The initial studies reported here suggest that this effect is mediated at the level of individual CTL, rather than through an alteration of CTL frequency in effector cell populations. Moreover, it seems unlikely that the fatty acids mediate their effect by altering membrane fluidity. |
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Authors:
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R Gill; W Clark |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 125 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1980 Aug |
Date Detail:
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Created Date: 1980-09-26 Completed Date: 1980-09-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 689-95 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism Animals Binding Sites Cell Membrane / immunology Cells, Cultured Concanavalin A / pharmacology Cytotoxicity, Immunologic* Dose-Response Relationship, Immunologic Fatty Acids / pharmacology* Female Immunologic Memory Kinetics Lymphocyte Culture Test, Mixed Mice Mice, Inbred C3H Mice, Inbred DBA Phospholipids / immunology* Thymidine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Fatty Acids; 0/Phospholipids; 11028-71-0/Concanavalin A; 50-89-5/Thymidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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