| Membrane saturated fatty acids and disease progression in multiple sclerosis patients. | |
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MedLine Citation:
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PMID: 19890702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The risk of developing multiple sclerosis is associated with increased dietary intake of saturated fatty acids. We determined the fatty acid composition within the different phospholipid fractions of red blood and peripheral blood mononuclear cell membranes of 31 patients diagnosed with multiple sclerosis and 30 healthy control subjects using gas chromatography. Individual saturated fatty acids were correlated with the severity of neurological outcome as measured by the Kurtzke Expanded Disability Status Scale. Significant increases were found in multiple sclerosis peripheral blood mononuclear cell membrane sphingomyelin C14:0 and phosphatidylinositol C22:0. In the peripheral blood mononuclear cell membranes, C22:0 and C24:0 showed positive correlations, while C14:0, C16:0 and C20:0 showed inverse correlations with the Functional System Scores. In conclusion, this study is in accordance with previous studies that have shown an increase in shorter long-chain SATS in MS patients. In addition, this study also showed that higher C14:0 and C16:0 reflected better disease outcome as demonstrated by the inverse correlation with the EDSS and FSS. We have also characterized the specific SATS, that is, long-chain SATS that may increase the risk of developing MS. |
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Authors:
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G M Hon; M S Hassan; S J van Rensburg; S Abel; R T Erasmus; T Matsha |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-05 |
Journal Detail:
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Title: Metabolic brain disease Volume: 24 ISSN: 1573-7365 ISO Abbreviation: Metab Brain Dis Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-04-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610370 Medline TA: Metab Brain Dis Country: United States |
Other Details:
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Languages: eng Pagination: 561-8 Citation Subset: IM |
Affiliation:
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Department of Bio-Medical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, P O Box 1906, Bellville, 7530, Cape Town, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / analysis, metabolism Causality Dietary Fats / adverse effects*, metabolism* Disability Evaluation Disease Progression Erythrocytes / metabolism Fatty Acids / metabolism* Female Humans Leukocytes, Mononuclear / metabolism Male Membrane Lipids / metabolism* Middle Aged Molecular Weight Multiple Sclerosis / etiology, metabolism*, physiopathology Phosphatidylinositols / analysis, metabolism Sphingomyelins / analysis, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Dietary Fats; 0/Fatty Acids; 0/Membrane Lipids; 0/Phosphatidylinositols; 0/Sphingomyelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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