Document Detail

Membrane properties in chronic inflammatory demyelinating polyneuropathy.
MedLine Citation:
PMID:  11701598     Owner:  NLM     Status:  MEDLINE    
Threshold tracking was used to compare excitability properties (stimulus-response curves, strength-duration properties, recovery cycle and threshold electrotonus) of the median nerve in 11 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and 25 healthy controls. Stimulus-response curves were significantly different: threshold was much higher, the slope of the curves reduced and the spread of the thresholds greater in the CIDP group. The strength-duration time constant (tau(SD)) was significantly shorter and the rheobase higher in the CIDP group. In the recovery cycle, the CIDP group had less refractoriness, supernormality and late subnormality than healthy controls, but the duration of the relatively refractory period was normal. These changes in tau(SD) and the recovery cycle were not those previously predicted. There were no consistent changes in threshold electrotonus, suggesting that, for the studied axons, there are no consistent changes in accommodation properties that depend on internodal conductances. It is difficult to explain these changes in excitability on the basis of a change in membrane potential, or solely as the result of demyelination, and it is possible that other morphological factors such as variable remyelination and inflammatory oedema affected axonal excitability in the patients.
C Cappelen-Smith; S Kuwabara; C S Lin; I Mogyoros; D Burke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  124     ISSN:  0006-8950     ISO Abbreviation:  Brain     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-09     Completed Date:  2002-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  England    
Other Details:
Languages:  eng     Pagination:  2439-47     Citation Subset:  AIM; IM    
Prince of Wales Medical Research Institute, University of New South Wales, Australia.
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MeSH Terms
Action Potentials / physiology*
Axons / pathology,  physiology
Cell Membrane / physiology
Demyelinating Diseases / pathology,  physiopathology
Median Nerve / pathology,  physiopathology
Middle Aged
Motor Neurons / pathology*,  physiology*,  ultrastructure
Neural Conduction
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / pathology*,  physiopathology*
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