Document Detail

Membrane lipids and cell death: an overview.
MedLine Citation:
PMID:  15081856     Owner:  NLM     Status:  MEDLINE    
In this article we overview major aspects of membrane lipids in the complex area of cell death, comprising apoptosis and various forms of programmed cell death. We have focused here on glycerophospholipids, the major components of cellular membranes. In particular, we present a detailed appraisal of mitochondrial lipids that attract increasing interest in the field of cell death, while the knowledge of their re-modelling and traffic remains limited. It is hoped that this review will stimulate further studies by lipid experts to fully elucidate various aspects of membrane lipid homeostasis that are discussed here. These studies will undoubtedly reveal new and important connections with the established players of cell death and their action in promoting or blocking membrane alteration of mitochondria and other organelles. We conclude that the new dynamic era of cell death research will pave the way for a better understanding of the 'chemistry of apoptosis'.
Ileana M Cristea; Mauro Degli Esposti
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  129     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-14     Completed Date:  2004-12-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  133-60     Citation Subset:  IM    
Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, USA.
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MeSH Terms
Apoptosis / physiology*
Cell Death / physiology
Cell Membrane / metabolism*
Intracellular Membranes / metabolism
Membrane Lipids / metabolism*
Mitochondria / metabolism*
Proto-Oncogene Proteins c-bcl-2 / metabolism
Signal Transduction / physiology*
Reg. No./Substance:
0/Membrane Lipids; 0/Proto-Oncogene Proteins c-bcl-2

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