Document Detail

Membrane-linked systems preventing superoxide formation.
MedLine Citation:
PMID:  9337489     Owner:  NLM     Status:  MEDLINE    
New facts and ideas concerning the membrane-linked mechanisms preventing superoxide formation are summarised here. It is assumed that aerobic cells possess several lines of anti-ROS defence, including optimisation of the intracellular oxygen concentration, decrease in the concentration and life-time of one-electron O2 reductants such as CoQH; and mitochondrial and cell selections, i.e. elimination of mitochondria and cells producing ROS at high rate. It is postulated that ROS-dependent pore opening and ROS-dependent apoptosis are involved in mitochondrial and cell selections.
V P Skulachev
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Bioscience reports     Volume:  17     ISSN:  0144-8463     ISO Abbreviation:  Biosci. Rep.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-11-24     Completed Date:  1997-11-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8102797     Medline TA:  Biosci Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-66     Citation Subset:  IM    
Department of Bioenergetics, A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia.
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MeSH Terms
Aconitate Hydratase / metabolism
Azotobacter / metabolism
Bacteria / metabolism
Cell Membrane / drug effects,  metabolism*
Cell Membrane Permeability
DNA, Mitochondrial / drug effects,  metabolism
Mitochondria / metabolism
Plants / metabolism
Reactive Oxygen Species / metabolism*
Superoxides / metabolism*
Uncoupling Agents / metabolism,  pharmacology
Reg. No./Substance:
0/DNA, Mitochondrial; 0/Reactive Oxygen Species; 0/Uncoupling Agents; 11062-77-4/Superoxides; EC Hydratase

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