| Membrane fusion induced by influenza virus hemagglutinin requires protein bound fatty acids. | |
| | |
MedLine Citation:
|
PMID: 3720946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The low pH-dependent fusion of lipid membranes induced by two types of the fatty acylated influenza viral hemagglutinin has been studied by use of an energy transfer assay. When protein bound fatty acids were released from the hemagglutinin by hydroxylamine treatment viral fusion activity was inhibited. The extent of fusion inhibition correlates with the amount of fatty acids cleaved from the hemagglutinin. Virosomes prepared from fowl plague virus containing fatty acid free hemagglutinin showed a much lower fusion activity than control virosomes containing fatty acylated hemagglutinin. The hydroxylamine treatment applied has no detectable effects on the virus other than fatty acid release from its spike glycoproteins. These results support our previous hypothesis that protein bound fatty acids are involved in the induction of membrane fusion by the influenza hemagglutinin. |
| | |
Authors:
|
B Lambrecht; M F Schmidt |
Related Documents
:
|
4085506 - Myocardial uptake of radioactively labelled free fatty acids. 22002626 - Reduced expression of fata thioesterases in arabidopsis affects the oil content and fat... 19047536 - International union of pharmacology. lxxi. free fatty acid receptors ffa1, -2, and -3: ... 6624876 - The clonal characteristics of human aortic intima. comparison with fatty streaks and no... 15214436 - Saponification of esters of chiral alpha-amino acids anchored through their amine funct... 11470266 - Oligosaccharyltransferase is highly specific for the hydroxy amino acid in asn-xaa-thr/... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: FEBS letters Volume: 202 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1986 Jun |
Date Detail:
|
Created Date: 1986-07-30 Completed Date: 1986-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 127-32 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Chick Embryo Dogs Electrophoresis, Polyacrylamide Gel Energy Transfer Fatty Acids / physiology* Fibroblasts Hemagglutinins, Viral* Hemolysis Hydrogen-Ion Concentration Hydroxylamine Hydroxylamines / pharmacology Kidney Kinetics Membrane Fusion* Orthomyxoviridae / immunology* Protein Binding |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids; 0/Hemagglutinins, Viral; 0/Hydroxylamines; 7803-49-8/Hydroxylamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: 4-Benzoyl- and 4-benzyl-1,2,3-triazol-N-acetic acids, in vitro inhibitors of the prostaglandin synth...
Next Document: Role of catalase in metabolism of hydrogen peroxide by the perfused rat heart.