Document Detail

Membrane fusion induced by influenza virus hemagglutinin requires protein bound fatty acids.
MedLine Citation:
PMID:  3720946     Owner:  NLM     Status:  MEDLINE    
The low pH-dependent fusion of lipid membranes induced by two types of the fatty acylated influenza viral hemagglutinin has been studied by use of an energy transfer assay. When protein bound fatty acids were released from the hemagglutinin by hydroxylamine treatment viral fusion activity was inhibited. The extent of fusion inhibition correlates with the amount of fatty acids cleaved from the hemagglutinin. Virosomes prepared from fowl plague virus containing fatty acid free hemagglutinin showed a much lower fusion activity than control virosomes containing fatty acylated hemagglutinin. The hydroxylamine treatment applied has no detectable effects on the virus other than fatty acid release from its spike glycoproteins. These results support our previous hypothesis that protein bound fatty acids are involved in the induction of membrane fusion by the influenza hemagglutinin.
B Lambrecht; M F Schmidt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  202     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-30     Completed Date:  1986-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
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MeSH Terms
Chick Embryo
Electrophoresis, Polyacrylamide Gel
Energy Transfer
Fatty Acids / physiology*
Hemagglutinins, Viral*
Hydrogen-Ion Concentration
Hydroxylamines / pharmacology
Membrane Fusion*
Orthomyxoviridae / immunology*
Protein Binding
Reg. No./Substance:
0/Fatty Acids; 0/Hemagglutinins, Viral; 0/Hydroxylamines; 7803-49-8/Hydroxylamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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