| Membrane fatty acid levels as a predictor of treatment response in chronic schizophrenia. | |
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MedLine Citation:
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PMID: 20800904 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abnormal fatty acid composition in neural membranes, that is, the balance between essential polyunsaturated fatty acids (EPUFAs) and saturated fatty acids, has been suggested to be related to the psychotic symptoms and cognitive impairment of schizophrenia. This study was conducted to test the hypothesis that the ability of atypical antipsychotic drugs to ameliorate positive symptoms and cognitive function relevant to daily living would be predicted by baseline EPUFAs concentrations in the erythrocyte membrane in subjects with schizophrenia. A total of 24 actively psychotic patients with schizophrenia participated in the study. After blood drawing, they were treated with olanzapine or perospirone. The Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for Assessment of Negative symptoms (SANS), as well as the script tasks, a measure of event schema recognition, were administered at baseline and 3months after the start of treatment. Erythrocyte membrane fatty acid levels were analysed using a gas chromatography system. Scores of SAPS and SANS, as well as script task performance, were improved during treatment with either antipsychotic drug. Regression analysis indicates baseline EPUFAs concentrations were positively and negatively related with percent improvement of positive symptoms and script task performance, respectively. The results of this study suggest composition of phospholipids in the erythrocyte membrane provide a feasible marker to predict treatment response in patients with schizophrenia. |
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Authors:
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Tomiki Sumiyoshi; Yuko Higuchi; Mie Matsui; Hiroko Itoh; Takashi Uehara; Toru Itoh; Hirofumi Arai; Chieko Takamiya; Michio Suzuki; Masayoshi Kurachi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Psychiatry research Volume: 186 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 23-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan. |
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