Document Detail


Membrane dynamics and interactions in measles virus dendritic cell infections.
MedLine Citation:
PMID:  22963539     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Viral entry, compartimentalization and transmission depend on the formation of membrane lipid/protein microdomains concentrating receptors and signalosomes. Dendritic cells (DCs) are prime targets for measles virus (MV) infection and this interaction promotes immune activation and generalized immunosuppression, yet also MV transport to secondary lymphatics where transmission to T cells occurs. In addition to MV trapping, DC-SIGN interaction can enhance MV uptake by activating cellular sphingomyelinases and thereby, vertical surface transport of its entry receptor CD150. To exploit DCs as Trojan horses for transport, MV promotes DC maturation accompanied by mobilization, and restrictions of viral replication in these cells may support this process. MV infected DCs are unable to support formation of functional immune synapses with conjugating T cells and signaling via viral glycoproteins or repulsive ligands (such as semaphorins) play a key role in the induction of T cell paralysis. In the absence of antigen recognition, MV transmission from infected DCs to T cells most likely involves formation of poly-conjugates which concentrate viral structural proteins, viral receptors and with components enhancing either viral uptake or conjugate stability. Because DCs barely support production of infectious MV particles, these organized interfaces are likely to represent virological synapses essential for MV transmission.
Authors:
Elita Avota; Susanne Koethe; Sibylle Schneider-Schaulies
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-11
Journal Detail:
Title:  Cellular microbiology     Volume:  -     ISSN:  1462-5822     ISO Abbreviation:  Cell. Microbiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883691     Medline TA:  Cell Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Institute for Virology and Immunobiology, University of Wuerzburg, Versbacher Str. 7, 97878, Wuerzburg, Germany.
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