Document Detail

Membrane dynamics and interactions in measles virus dendritic cell infections.
MedLine Citation:
PMID:  22963539     Owner:  NLM     Status:  Publisher    
Viral entry, compartimentalization and transmission depend on the formation of membrane lipid/protein microdomains concentrating receptors and signalosomes. Dendritic cells (DCs) are prime targets for measles virus (MV) infection and this interaction promotes immune activation and generalized immunosuppression, yet also MV transport to secondary lymphatics where transmission to T cells occurs. In addition to MV trapping, DC-SIGN interaction can enhance MV uptake by activating cellular sphingomyelinases and thereby, vertical surface transport of its entry receptor CD150. To exploit DCs as Trojan horses for transport, MV promotes DC maturation accompanied by mobilization, and restrictions of viral replication in these cells may support this process. MV infected DCs are unable to support formation of functional immune synapses with conjugating T cells and signaling via viral glycoproteins or repulsive ligands (such as semaphorins) play a key role in the induction of T cell paralysis. In the absence of antigen recognition, MV transmission from infected DCs to T cells most likely involves formation of poly-conjugates which concentrate viral structural proteins, viral receptors and with components enhancing either viral uptake or conjugate stability. Because DCs barely support production of infectious MV particles, these organized interfaces are likely to represent virological synapses essential for MV transmission.
Elita Avota; Susanne Koethe; Sibylle Schneider-Schaulies
Related Documents :
24891839 - Pepsin-pancreatin protein hydrolysates from extruded amaranth inhibit markers of athero...
24137459 - Inhibition of autophagy by 3-ma enhances endoplasmic reticulum stress-induced apoptosis...
25064339 - Doliroside a attenuates monosodium urate crystals-induced inflammation by targeting nlr...
24953459 - In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune...
24361309 - Anti-inflammatory effects of chicanine on murine macrophage by down-regulating lps-indu...
23349929 - Distinct profiles of effector cytokines mark the different phases of crohn's disease.
16436509 - Yeast amid homologue ndi1p displays respiration-restricted apoptotic activity and is in...
20018629 - Presenilin/gamma-secretase cleaves cd46 in response to neisseria infection.
12432449 - In vivo response of neutrophils and epithelial cells to lipopolysaccharide injected int...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-11
Journal Detail:
Title:  Cellular microbiology     Volume:  -     ISSN:  1462-5822     ISO Abbreviation:  Cell. Microbiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883691     Medline TA:  Cell Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Institute for Virology and Immunobiology, University of Wuerzburg, Versbacher Str. 7, 97878, Wuerzburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Screening of selected ethnomedicinal plants from South Africa for larvicidal activity against the mo...
Next Document:  Artificial forisomes are ideal models of forisome assembly and activity that allow the development o...