| Membrane dynamics in the action of dibutyryl adenosine 3':5'-cyclic monophosphate and testosterone on mammalian cells. | |
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MedLine Citation:
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PMID: 4340166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The first manifestation of reverse transformation, in which a permanent epithelial-like cell is reversibly transformed into a fibroblast-like cell by dibutyryl adenosine cyclic 3':5'-monophosphate, is the disappearance of a set of violently extending and retracting knobbed structures on the cell membrane with consequent tranquilization of the membrane. The cell then elongates to assume a fibroblast-like morphology. Permanently fibroblast-like cells, which have smooth membranes, can be changed into knobbed epithelial-like cells by the addition of either colcemid or cytochalasin B, agents that disorganize one or the other component, respectively, of the microtubular-microfibrillar system. Permanently smoothmembraned, epithelial-like cells also become knobbed by such treatment. All of these knobbed epithelial-like cells can be converted into smooth-membraned fibroblast-like cells by dibutyryl cAMP alone or with the aid of supporting molecules like testosterone. It is proposed that these are general phenomena and that the knobbed epithelial-like forms and the more highly differentiated smooth-membraned fibroblast-like cells represent extreme situations with respect to the degree of organization of the microtubular-microfibrillar system inside the cell. |
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Authors:
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T T Puck; C A Waldren; A W Hsie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 69 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1972 Jul |
Date Detail:
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Created Date: 1972-09-22 Completed Date: 1972-09-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1943-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Products / pharmacology Butyrates / pharmacology Cell Line Cell Membrane / drug effects* Cricetinae Cyclic AMP / pharmacology* Demecolcine / pharmacology Drug Synergism Female Hela Cells / cytology, drug effects* Indoles / pharmacology Lung / cytology, drug effects* Microtubules / drug effects Motion Pictures as Topic Ovary / cytology, drug effects* Photomicrography Testosterone / pharmacology* Vinblastine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 0/Butyrates; 0/Indoles; 477-30-5/Demecolcine; 58-22-0/Testosterone; 60-92-4/Cyclic AMP; 865-21-4/Vinblastine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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