| Membrane curvature and mechanisms of dynamic cell membrane remodelling. | |
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MedLine Citation:
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PMID: 16319878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization of curvature scaffolding proteins and the reversible insertion of protein regions that act like wedges in membranes. There is an interplay between curvature-generating and curvature-sensing proteins during vesicle budding. This is seen during vesicle budding and in the formation of microenvironments. On a larger scale, membrane curvature is a prime player in growth, division and movement. |
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Authors:
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Harvey T McMahon; Jennifer L Gallop |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature Volume: 438 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-01 Completed Date: 2005-12-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
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Languages: eng Pagination: 590-6 Citation Subset: IM |
Affiliation:
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MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. hmm@mrc-lmb.cam.ca.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Membrane
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chemistry*,
metabolism* Cytoskeleton / metabolism Membrane Lipids / metabolism Membrane Proteins / chemistry, metabolism Microtubules / metabolism Molecular Motor Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Membrane Lipids; 0/Membrane Proteins; 0/Molecular Motor Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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