Document Detail

Membrane cerebral lipids in Rett syndrome.
MedLine Citation:
PMID:  1878098     Owner:  NLM     Status:  MEDLINE    
The lipid membrane composition of cerebral tissue from 5 patients with classic Rett syndrome, ages 12-30 years, and from 14 age-matched controls was studied. The results demonstrated a selective loss of myelin-associated lipids and an enrichment of gangliosides in temporal white matter. The ganglioside pattern revealed an increase of astroglial cell-associated gangliosides and reduced proportions of gangliosides GD1a and GT1b. This latter finding may be crucial in synaptic function. The fatty acid compositions of ethanolamine phosphoglyceride, choline phosphoglyceride, and galactosylceramide were normal.
A Y Lekman; B A Hagberg; L T Svennerholm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric neurology     Volume:  7     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1991-10-01     Completed Date:  1991-10-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  186-90     Citation Subset:  IM    
Department of Psychiatry, University of Göteborg, Sweden.
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MeSH Terms
Brain / pathology*
Cholesterol / metabolism
Death, Sudden / pathology
Frontal Lobe / pathology
Gangliosides / metabolism
Membrane Lipids / metabolism*
Myelin Proteins / metabolism
Phospholipids / metabolism
Rett Syndrome / pathology*
Synaptic Membranes / pathology*
Temporal Lobe / pathology
Reg. No./Substance:
0/Gangliosides; 0/Membrane Lipids; 0/Myelin Proteins; 0/Phospholipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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