Document Detail


Membrane cerebral lipids in Rett syndrome.
MedLine Citation:
PMID:  1878098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lipid membrane composition of cerebral tissue from 5 patients with classic Rett syndrome, ages 12-30 years, and from 14 age-matched controls was studied. The results demonstrated a selective loss of myelin-associated lipids and an enrichment of gangliosides in temporal white matter. The ganglioside pattern revealed an increase of astroglial cell-associated gangliosides and reduced proportions of gangliosides GD1a and GT1b. This latter finding may be crucial in synaptic function. The fatty acid compositions of ethanolamine phosphoglyceride, choline phosphoglyceride, and galactosylceramide were normal.
Authors:
A Y Lekman; B A Hagberg; L T Svennerholm
Related Documents :
8675698 - Mechanism of free fatty acid-induced insulin resistance in humans.
7298658 - Biosynthesis in vitro of sialosylgalactosyldiacylglycerol by mouse brain microsomes.
7172628 - Skin surface lipids of the cow.
4045218 - Lipid composition and acid hydrolase content of lamellar granules of fetal rat epidermis.
1107448 - Genetic typing of alpha1-antitrypsin by immunofixation electrophoresis, identification ...
10826518 - Detection of functionally different types of pathological autoantibodies against thyrot...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric neurology     Volume:  7     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1991-10-01     Completed Date:  1991-10-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  186-90     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Göteborg, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain / pathology*
Child
Cholesterol / metabolism
Death, Sudden / pathology
Female
Frontal Lobe / pathology
Gangliosides / metabolism
Humans
Membrane Lipids / metabolism*
Myelin Proteins / metabolism
Phospholipids / metabolism
Rett Syndrome / pathology*
Synaptic Membranes / pathology*
Temporal Lobe / pathology
Chemical
Reg. No./Substance:
0/Gangliosides; 0/Membrane Lipids; 0/Myelin Proteins; 0/Phospholipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cortical blindness in children: a study of etiology and prognosis.
Next Document:  Magnetic resonance imaging in preterm infants.