Document Detail


Membrane Fc-IgG and C3b receptors on myeloid leukaemia cells: a comparison with cytoplasmic acid naphthyl acetate esterase cytochemistry.
MedLine Citation:
PMID:  6221035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Membrane receptors for IgG and C3b were examined on blast cells from 57 cases of acute myeloid leukaemia. These acute leukaemias were classified as myeloblastic, myelomonocytic or monocytic following morphological, cytochemical, and immunological investigations. The membrane receptors of leukaemic blast cells appear to be directly related to the degree of monocytic differentiation with the lowest receptor activities found in acute myeloblastic leukaemia. A comparison was also made between receptor and cytoplasmic acid naphthyl acetate esterase (ANAE) activities in 29 morphologically and immunologically-defined myelomonocytic and monocytic leukaemias. This study revealed that the receptor-positive "monocytic component" in a significant proportion of cases showed unexpectedly weak or negative ANAE reactions suggesting a more cautious approach to the interpretation of ANAE cytochemistry in acute leukaemias. The normal development of cytoplasmic ANAE and membrane receptors is also discussed and compared with their abnormal patterns of expression associated with leukaemic transformation.
Authors:
C S Scott; A G Bynoe; D C Linch; C Allen; D Hough; B E Roberts
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  36     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-23     Completed Date:  1983-06-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  555-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Carboxylic Ester Hydrolases / metabolism*
Complement C3b / metabolism*
Cytoplasm / enzymology
Humans
Immunoglobulin Fc Fragments / metabolism
Immunoglobulin G / metabolism*
Leukemia, Myeloid / classification,  enzymology,  immunology
Leukemia, Myeloid, Acute / classification,  enzymology,  immunology*
Monocytes / enzymology,  immunology
Naphthol AS D Esterase / metabolism*
Receptors, Complement / analysis*
Receptors, Complement 3b
Receptors, IgG
Receptors, Immunologic / analysis*
Chemical
Reg. No./Substance:
0/Immunoglobulin Fc Fragments; 0/Immunoglobulin G; 0/Receptors, Complement; 0/Receptors, Complement 3b; 0/Receptors, IgG; 0/Receptors, Immunologic; 80295-43-8/Complement C3b; EC 3.1.-/Naphthol AS D Esterase; EC 3.1.1.-/Carboxylic Ester Hydrolases
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