| Memantine ameliorates scopolamine-induced amnesia in chicks trained on taste-avoidance learning. | |
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MedLine Citation:
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PMID: 20170739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In day-old chicks trained on the one-trial taste-avoidance task, activation of NMDA receptors by glutamate is particularly important in the initial stages of memory consolidation. In addition, acetylcholine receptor activation has been shown to be a necessary component of memory formation for this task because injection of scopolamine produces amnesia. Memantine, a non-competitive NMDA receptor antagonist, improves memory formation under certain impairing circumstances, despite inhibiting the activation of NMDA receptors. The present experiments tested the hypothesis that memantine can ameliorate scopolamine-induced amnesia in day-old chicks (Gallus gallus domesticus) trained on the one-trial taste-avoidance task. Three experiments assessed the effects of scopolamine, memantine, and glutamate in this task. The results of Experiment 1 demonstrated that 50.0mM scopolamine produces significant amnesia. In Experiment 2, 1.0mM memantine reversed the scopolamine-induced amnesia, while other doses were ineffective. In Experiment 3, injection of 50.0mM glutamate in combination with scopolamine reversed the memantine amelioration. These results indicate a relationship between glutamate and acetylcholine in memory formation in the day-old chick. |
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Authors:
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Teresa A Barber; Megan K Haggarty |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-17 |
Journal Detail:
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Title: Neurobiology of learning and memory Volume: 93 ISSN: 1095-9564 ISO Abbreviation: Neurobiol Learn Mem Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508166 Medline TA: Neurobiol Learn Mem Country: United States |
Other Details:
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Languages: eng Pagination: 540-5 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Psychology, Dickinson College, Carlisle, PA 17013, USA. barber@dickinson.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amnesia
/
chemically induced,
drug therapy*,
metabolism Animals Avoidance Learning / drug effects*, physiology Chickens Cholinergic Antagonists / pharmacology Excitatory Amino Acid Antagonists / administration & dosage, pharmacology Glutamic Acid / metabolism Male Memantine / administration & dosage, pharmacology* Memory / drug effects*, physiology Neuropsychological Tests Nootropic Agents / administration & dosage, pharmacology* Receptors, Cholinergic / metabolism Receptors, Glutamate / metabolism Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors, metabolism Scopolamine / pharmacology Taste Perception / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Cholinergic Antagonists; 0/Excitatory Amino Acid Antagonists; 0/Nootropic Agents; 0/Receptors, Cholinergic; 0/Receptors, Glutamate; 0/Receptors, N-Methyl-D-Aspartate; 19982-08-2/Memantine; 51-34-3/Scopolamine; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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