Document Detail

Melting graft-wound syndrome.
MedLine Citation:
PMID:  9710725     Owner:  NLM     Status:  MEDLINE    
Progressive epithelial loss (melting) from a previously well-taken graft, healed burn wound, or healed donor site is a significant problem in the treatment of patients with burn injuries. For many years, such epithelial loss was attributed to the growth of Streptococcus spp; however, we recently have encountered progressive epithelial melting without significant colonization or infection with Streptococcus spp. We retrospectively reviewed 1035 cases admitted from January 1994 to July 1996 and then collected data prospectively from 324 patients admitted to the University of Washington Burn Center from August 1996 to May 1997. Melting graft-wound syndrome developed in 29 patients. Swab wound cultures from these patients mainly grew Staphylococcus aureus, and none grew Streptococcus spp. All patients were treated with systemic antibiotics and local wound care. Twenty-seven patients healed spontaneously, but two underwent debridement and re-autografting to close the wounds. The melting graft-wound is a significant clinical problem, and its incidence appears to be increasing. The pathophysiology, clinical course, and treatment of the melting graft-wound syndrome are not well understood, and there is no description of it in the literature. This study describes the clinical features of the syndrome.
H Matsumura; N A Meyer; R Mann; D M Heimbach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of burn care & rehabilitation     Volume:  19     ISSN:  0273-8481     ISO Abbreviation:  J Burn Care Rehabil     Publication Date:    1998 Jul-Aug
Date Detail:
Created Date:  1998-10-19     Completed Date:  1998-10-19     Revised Date:  2006-08-15    
Medline Journal Info:
Nlm Unique ID:  8110188     Medline TA:  J Burn Care Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  IM    
University of Washington Burn Center, Harborview Medical Center, Seattle 98104, USA.
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MeSH Terms
Burns / surgery*
Child, Preschool
Middle Aged
Postoperative Complications
Prospective Studies
Retrospective Studies
Skin Transplantation*
Staphylococcal Infections / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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