| Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2. | |
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MedLine Citation:
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PMID: 2375756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Melittin stimulates glycogenolysis and induces vasoconstriction in perfused rat liver. The effect was rapid and associated with production and release of prostaglandin D2 and thromboxane B2. Indomethacin blocked the release of these eicosanoids and the stimulation of glycogenolysis induced by melittin. Ibuprofen blocked the release of prostaglandin D2 induced by melittin and markedly attenuated that of thromboxane B2. Interestingly, the initial burst of glucose output induced by melittin was not inhibited by ibuprofen, although the duration of the glycogenolytic action of the peptide was greatly diminished. |
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Authors:
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J A García-Sáinz; S M Hernández-Sotomayor; M Macías-Silva |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Biochemical journal Volume: 269 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-08-27 Completed Date: 1990-08-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 273-5 Citation Subset: IM |
Affiliation:
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Departamento de Bioenergética, Universidad Nacional Autónoma de México, D.F. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bee Venoms / pharmacology* Female Glycogen / metabolism* Ibuprofen / pharmacology Indomethacin / pharmacology Kinetics Liver / blood supply, drug effects, metabolism* Melitten / pharmacology* Peptides Prostaglandin D2 / biosynthesis* Rats Rats, Inbred Strains Thromboxane B2 / biosynthesis* Vasoconstriction / drug effects Wasp Venoms / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Bee Venoms; 0/Peptides; 0/Wasp Venoms; 15687-27-1/Ibuprofen; 20449-79-0/Melitten; 41598-07-6/Prostaglandin D2; 53-86-1/Indomethacin; 54397-85-2/Thromboxane B2; 72093-21-1/mastoparan; 9005-79-2/Glycogen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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