Document Detail

Melittin stimulates Na entry, Na-K pump activity and DNA synthesis in quiescent cultures of mouse cells.
MedLine Citation:
PMID:  6261955     Owner:  NLM     Status:  MEDLINE    
Melittin, an amphipatic polypeptide, increases several fold the activity of Na-K pump in quiescent Swiss 3T3 cells. As with other growth factors, melittin increases the activity of the pump by increasing Na entry into the cell. In contrast, other early responses are not elicited by the toxin. At concentrations that promote ion fluxes, melittin stimulates DNA synthesis in quiescent mouse cells acting synergistically with insulin, epidermal growth factor and with the growth factor released by SV40 BHK cells. In contrast, melittin does not interact synergistically with either phorbol esters of vasopressin. The cellular effects of melittin are consistent with the proposal that ion fluxes signal the initiation of mitogenesis in quiescent cells.
E Rozengurt; T D Gelehrter; A Legg; P Pettican
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  23     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  781-8     Citation Subset:  IM    
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MeSH Terms
Aminobutyric Acids / metabolism
Bee Venoms / pharmacology*
Cells, Cultured
DNA / biosynthesis*
Deoxyglucose / metabolism
Drug Synergism
Growth Substances / pharmacology
Insulin / pharmacology
Melitten / pharmacology*
Monensin / pharmacology
Sodium / metabolism*
Sodium-Potassium-Exchanging ATPase / metabolism*
Uridine / metabolism
Reg. No./Substance:
0/Aminobutyric Acids; 0/Bee Venoms; 0/Growth Substances; 11061-68-0/Insulin; 154-17-6/Deoxyglucose; 17090-79-8/Monensin; 20449-79-0/Melitten; 58-96-8/Uridine; 7440-23-5/Sodium; 9007-49-2/DNA; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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