Document Detail

Melatonin for the treatment of tardive dyskinesia.
MedLine Citation:
PMID:  12841828     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review the available literature regarding the use of melatonin in the treatment of tardive dyskinesia (TD). DATA SOURCES: Literature was identified through MEDLINE (1966-September 2002), PsycINFO (1967-September 2002), and references of relevant articles. Review articles, case reports/series, and animal and human studies were reviewed. DATA SYNTHESIS: Melatonin has been investigated in TD based on its antioxidant properties. Animal studies and several human case series describe an association between melatonin and TD. Two recent, controlled studies evaluated the role of melatonin in the treatment of TD. CONCLUSIONS: There is a paucity of data evaluating the use of melatonin in TD. Both of the controlled studies evaluating its use are limited by methodologic issues. Although the most recent trial did report a statistically significant improvement in TD with melatonin, these results are not considered to be clinically significant. There are inadequate data at the present time to support the use of melatonin in patients with TD.
Leigh Anne Nelson; J Michael McGuire; Sarah N Hausafus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  37     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-07-04     Completed Date:  2003-09-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1128-31     Citation Subset:  IM    
St. Louis College of Pharmacy/St. Louis University School of Medicine, St. Louis, MO, USA.
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MeSH Terms
Antipsychotic Agents / adverse effects
Clinical Trials as Topic
Dyskinesia, Drug-Induced / drug therapy*
Melatonin / therapeutic use*
Pineal Gland / physiopathology
Reg. No./Substance:
0/Antipsychotic Agents; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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