| Melatonin treatment in peri- and postmenopausal women elevates serum high-density lipoprotein cholesterol levels without influencing total cholesterol levels. | |
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MedLine Citation:
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PMID: 18298467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the effects of melatonin on lipid metabolism in peri- and postmenopausal women. Forty-six women were enrolled in these studies. The relationship between night-time serum melatonin levels and serum total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol was investigated in 36 women. Night-time serum melatonin levels had a negative correlation with serum total cholesterol and LDL-cholesterol, and a loose positive correlation with HDL-cholesterol. To examine the effects of exogenous melatonin on lipid metabolism, serum levels of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides were determined in 10 women before the onset of therapy and after 1 month of oral melatonin administration (1 mg melatonin daily). Melatonin administration significantly increased the serum levels of HDL-cholesterol. These results show that melatonin may influence cholesterol metabolism and suggest that the melatonin administration may become a new medical application for improvement of lipid metabolism and prevention of cardiovascular disease in peri- and postmenopausal women. |
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Authors:
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Hiroshi Tamura; Yasuhiko Nakamura; Akio Narimatsu; Yoshiaki Yamagata; Akihisa Takasaki; Russel J Reiter; Norihiro Sugino |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-19 |
Journal Detail:
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Title: Journal of pineal research Volume: 45 ISSN: 1600-079X ISO Abbreviation: J. Pineal Res. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-22 Completed Date: 2008-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8504412 Medline TA: J Pineal Res Country: Denmark |
Other Details:
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Languages: eng Pagination: 101-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan. hitamura@yamaguchi-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cholesterol, HDL / biosynthesis*, blood*, metabolism Cholesterol, LDL / blood Female Humans Melatonin / administration & dosage*, physiology Middle Aged Perimenopause / blood*, metabolism Postmenopause / blood*, metabolism Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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