Document Detail


Melatonin treatment in peri- and postmenopausal women elevates serum high-density lipoprotein cholesterol levels without influencing total cholesterol levels.
MedLine Citation:
PMID:  18298467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to investigate the effects of melatonin on lipid metabolism in peri- and postmenopausal women. Forty-six women were enrolled in these studies. The relationship between night-time serum melatonin levels and serum total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol was investigated in 36 women. Night-time serum melatonin levels had a negative correlation with serum total cholesterol and LDL-cholesterol, and a loose positive correlation with HDL-cholesterol. To examine the effects of exogenous melatonin on lipid metabolism, serum levels of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides were determined in 10 women before the onset of therapy and after 1 month of oral melatonin administration (1 mg melatonin daily). Melatonin administration significantly increased the serum levels of HDL-cholesterol. These results show that melatonin may influence cholesterol metabolism and suggest that the melatonin administration may become a new medical application for improvement of lipid metabolism and prevention of cardiovascular disease in peri- and postmenopausal women.
Authors:
Hiroshi Tamura; Yasuhiko Nakamura; Akio Narimatsu; Yoshiaki Yamagata; Akihisa Takasaki; Russel J Reiter; Norihiro Sugino
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-19
Journal Detail:
Title:  Journal of pineal research     Volume:  45     ISSN:  1600-079X     ISO Abbreviation:  J. Pineal Res.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-22     Completed Date:  2008-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8504412     Medline TA:  J Pineal Res     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  101-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan. hitamura@yamaguchi-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cholesterol, HDL / biosynthesis*,  blood*,  metabolism
Cholesterol, LDL / blood
Female
Humans
Melatonin / administration & dosage*,  physiology
Middle Aged
Perimenopause / blood*,  metabolism
Postmenopause / blood*,  metabolism
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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