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Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy.
MedLine Citation:
PMID:  21515247     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To analyze whether the antioxidant melatonin could reduce the hyperoxidative status in the blood of patients with Duchenne's muscular dystrophy. DESIGN AND METHODS: Ten patients aged 12.8±0.9years were treated with melatonin (60mg at 21:00h plus 10mg at 09:00h) for 9months, and erythrocyte markers of oxidative stress were determined at 3, 6, and 9months of treatment. Healthy age- and sex-matched subjects served as controls. RESULTS: Prior to treatment, the patients had higher glutathione disulfide/glutathione ratio and higher glutathione transferase and superoxide dismutase activities, and lower glutathione reductase activity than controls. After 3months of melatonin treatment, the hyperoxidative status of these patients was counteracted, being reduced to the normal redox state between 3 and 9months. CONCLUSION: These results, together with the reduction in the inflammatory process and in muscle injury recently reported in the same patients, support the efficacy of melatonin therapy in DMD patients.
Authors:
Mariam Chahbouni; Germaine Escames; Luis C López; Belén Sevilla; Carolina Doerrier; Antonio Muñoz-Hoyos; Antonio Molina-Carballo; Darío Acuña-Castroviejo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-15
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Instituto de Biotecnología, Centro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, Granada, Spain; Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain.
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