Document Detail

Melatonin together with noradrenaline augments contractions of human myometrium.
MedLine Citation:
PMID:  8982698     Owner:  NLM     Status:  MEDLINE    
The hormone melatonin is known to influence the circadian rhythm, and it probably also mediates some of the physiological changes that occur in the body at night. Inasmuch as uterine activity is greater during darkness, we investigated whether melatonin could modulate uterine contractility. Biopsies were performed during caesarean sections to obtain uterine tissue from women who had reached full term. The obtained samples were mounted in organ baths, and spontaneous contractions were recorded. Melatonin alone did not change myometrial contractility, whereas melatonin in combination with noradrenaline potentiated contractions. These results may indicate that melatonin plays a role in the timing of labour, since labour often begins late in the evening.
L G Mårtensson; R G Andersson; G Berg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  316     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-06-12     Completed Date:  1997-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  273-5     Citation Subset:  IM    
Department of Pharmacology, Faculty of Health Sciences, Linköping University, Sweden.
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MeSH Terms
Dose-Response Relationship, Drug
Melatonin / pharmacology*
Muscle Contraction / drug effects*
Myometrium / drug effects*
Norepinephrine / pharmacology*
Reg. No./Substance:
51-41-2/Norepinephrine; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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