Document Detail


Melatonin suppression in human subjects by bright and dim light in antarctica: time and season-dependent effects.
MedLine Citation:
PMID:  1584458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Full-spectrum light, of sufficiently high intensity, will suppress the secretion of melatonin at night in humans. Individual sensitivity to such suppression is variable, and the factors determining such sensitivity are largely unknown. By analogy with animal work previous short or long-term exposure to different light intensities may be an important determinant. We exploited the Antarctic environment to investigate these possibilities. Groups of healthy men, living on the British Antarctic Survey Base at Halley (75 degrees South) were exposed to dim (range 290-310 lux) and bright (range 2100-2300 lux) light either from 01.00-02.00 h or 05.00-0.600 h, both in winter and in summer. Plasma melatonin concentrations were determined by radioimmunoassay in serial blood samples taken before, during and after light treatment, and in control (darkness) conditions. Light suppression of melatonin was more effective in the latter part of the night in winter and this was particularly well-differentiated for dim light.
Authors:
J Owen; J Arendt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  137     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-06-18     Completed Date:  1992-06-18     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  IM    
Affiliation:
British Antarctic Survey Medical Unit, RGIT Survival Centre, Aberdeen, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antarctic Regions
Humans
Light*
Male
Melatonin / blood*
Seasons
Time Factors
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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