Document Detail

Melatonin reduction by lithium and albinism in quail and hamsters.
MedLine Citation:
PMID:  2555249     Owner:  NLM     Status:  MEDLINE    
Melatonin was measured by radioimmunoassay in several genetic strains of Japanese quail. Plasma melatonin (PM), measured at the nighttime peak, was highest in wild type quail reared on a diurnal lighting schedule; this PM peak was suppressed in continuous light. Albino quail had low melatonin levels, whether reared under diurnal conditions or in continuous light. Ocular melatonin was also suppressed in albinos and in dilute mutants. At midday sampling, melatonin was only half as high in albinos as in wild types. Intraocular pressure (IOP, daytime readings) was uniformly low in diurnal birds and was elevated in all quail reared under continuous light. Thus in pigmented birds, a high melatonin level was associated with high IOP, but in albinos displaying high IOP, ocular melatonin was not elevated. Lithium chloride, mixed in the feed, brought about a pronounced reduction in plasma, pineal, and ocular melatonin, in wild-type quail reared on a diurnal schedule. This confirms earlier findings in lithium-fed rats. Golden hamsters displayed a characteristic diurnal cycle of pineal melatonin, with a sharp middark peak; in albino hamsters, also kept on a diurnal schedule, this peak occurred at the same time, but albinos had melatonin levels only about one-third as high as those of pigmented animals.
J K Lauber; J Vriend
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General and comparative endocrinology     Volume:  76     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-10     Completed Date:  1990-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  414-20     Citation Subset:  IM    
Department of Zoology, University of Alberta, Edmonton, Canada.
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MeSH Terms
Albinism / metabolism,  veterinary*
Bird Diseases / metabolism*,  pathology
Chlorides / pharmacology*
Coturnix / metabolism*
Cricetinae / metabolism*
Eye / anatomy & histology,  metabolism
Intraocular Pressure
Lithium / pharmacology*
Lithium Chloride
Melatonin / metabolism*
Mesocricetus / metabolism*
Organ Size
Pineal Gland / metabolism
Quail / metabolism*
Rodent Diseases / metabolism,  pathology
Reg. No./Substance:
0/Chlorides; 73-31-4/Melatonin; 7439-93-2/Lithium; 7447-41-8/Lithium Chloride

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