| Melatonin prevents oxidant damage in various tissues of rats with hyperthyroidism. | |
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MedLine Citation:
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PMID: 16464477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impairment of thyroid functions brings about pathological changes in different organs of body. Findings of in vivo and in vitro studies indicate that thyroid hormones have a considerable impact on oxidative stress. Melatonin reduces oxidative damage through its free radical eliminating and direct anti-oxidant effects. The present study was undertaken to determine how a 3-week period of intraperitoneal melatonin administration affected oxidative damage caused in experimental hyperthyroidism in rat. The experimental animals were divided into 3 groups (control, hyperthyroidism, hyperthyroidism+melatonin). Malondialdehyde (MDA) and glutathione (GSH) levels were determined in different tissues. MDA levels in cerebral, liver and cardiac tissues in hyperthyroidism group were significantly higher than those in control and hyperthyroidism+melatonin supplemented groups (p<0.001). The highest GSH levels were observed in the group that was administered melatonin in addition to having hyperthyroidism (p<0.001). These results show that hyperthyroidism increased oxidative damage in cerebral, hepatic and cardiac tissues of rat. Melatonin supplementation may also suppress oxidative damage. |
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Authors:
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Rasim Mogulkoc; Abdulkerim Kasim Baltaci; Esma Oztekin; Leyla Aydin; Abdullah Sivrikaya |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-02-07 |
Journal Detail:
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Title: Life sciences Volume: 79 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-01 Completed Date: 2006-08-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 311-5 Citation Subset: IM |
Affiliation:
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Department of Physiology, Meram Medical School, Selcuk University, 42080 Konya, Turkey. mogulkoc@slcuk.du.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / administration & dosage* Brain / drug effects, metabolism Brain Chemistry / drug effects Glutathione / analysis Hyperthyroidism / metabolism* Infusions, Parenteral Liver / chemistry, drug effects, metabolism Male Malondialdehyde / analysis Melatonin / administration & dosage* Myocardium / chemistry, metabolism Oxidation-Reduction / drug effects Oxidative Stress / drug effects* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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