Document Detail

Melatonin negatively correlates with C-peptide after food intake.
MedLine Citation:
PMID:  18271676     Owner:  NLM     Status:  MEDLINE    
Melatonin plays a key role in the circadian timing system. At present, many other functions of melatonin are known. Question remains whether changes in endogenous melatonin may be associated with food intake. Hence, the levels of melatonin, C-peptide and glucose were followed during a daily regimen (16 hours) including standardized food intake using commercial kits. The diurnal profiles of the hormones and serum glucose were evaluated using ANOVA with Period and Subject as independent factors. Pearson's correlations and using a multiple stepwise backward regression model consisting of the time factor as a polynomial, and serum C-peptide and glucose assessed the correlations between melatonin and the remaining parameters. Our results showed a significant negative correlation between melatonin and C-peptide. The profile of melatonin was physiological, decreasing after wake-up, showing minor changes during the daytime and increasing in the evening. As documented, lesser alterations were indicated in the course of the melatonin daytime profile, which may reflect periodic food intake. Food intake is not the primary factor influencing the melatonin course. While previous studies have mostly considered the protective effect of melatonin in diabetic subjects, our study brought the results suggesting food intake as a factor contributing to daytime melatonin variation in humans. However, the physiological role of melatonin association with food intake in daytime remains in question and should be further investigated.
L Stárka; M Dusková; B Rácz; K Simůnková; M Hill; R Kancheva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-13
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  57 Suppl 1     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  S187-92     Citation Subset:  IM    
Institute of Endocrinology, Prague, Czech Republic.
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MeSH Terms
Blood Glucose / metabolism
C-Peptide / blood*
Circadian Rhythm / physiology*
Dietary Carbohydrates / administration & dosage
Eating / physiology*
Melatonin / blood*
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 0/Dietary Carbohydrates; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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