Document Detail

Melatonin and methimazole mimic short-day-induced fattening in gray mouse lemurs.
MedLine Citation:
PMID:  12954394     Owner:  NLM     Status:  MEDLINE    
Short-day-induced fattening was investigated in the small nocturnal primate Microcebus murinus. Animals were either transferred from long photoperiod (LP) to short photoperiod (SP) or maintained in LP and submitted to various treatments. Animals fed daily on 40 microg of melatonin (MEL) at two different times showed a significant increase in body mass compared to LP-exposed animals. This weight gain was more marked in animals fed with MEL 2 h before night onset, suggesting a critical period around the first hours of the night. The MEL-induced fattening was associated with an increase in food intake and a decrease in plasma thyroxin (T4) levels. On the other hand, a decrease in T4 plasma levels induced by two doses of methimazole (MET) led to either an increase (3 mg/day) or a decrease (10 mg/day) of body mass, suggesting a role of thyroid hormones in the photoperiodic regulation of body mass. The MET-induced fattening did not involve any change in food intake. These findings suggest that autumn fattening in the gray mouse lemur proceeds from two distinct mechanisms. First, an increase of food intake may result in the SP-induced increase in MEL secretion. Second, a decrease of energy expenditure may be due to the MEL-induced hypothyroidism.
F Génin; A Schilling; B Claustrat
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  79     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-04     Completed Date:  2004-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  553-9     Citation Subset:  IM    
Laboratoire d'Ecologie Générale, CNRS UMR 8571, MNHN, 4 avenue du Petit Château, F-91800 Brunoy, France.
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MeSH Terms
Adipose Tissue / drug effects,  metabolism*
Antithyroid Agents / pharmacology
Appetite Regulation / drug effects,  physiology*
Body Composition / drug effects,  physiology*
Cheirogaleidae / metabolism*
Melatonin / metabolism*
Methimazole / pharmacology
Thyroid Gland / drug effects,  metabolism
Thyroid Hormones / metabolism
Thyroxine / drug effects,  metabolism*
Reg. No./Substance:
0/Antithyroid Agents; 0/Thyroid Hormones; 60-56-0/Methimazole; 73-31-4/Melatonin; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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