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Melatonin or l-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole.
MedLine Citation:
PMID:  21362032     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
  Melatonin and l-tryptophan (Trp) are highly gastroprotective in humans, but no study has assessed their impact on healing of chronic gastroduodenal ulcers in humans. Three groups (A, B and C) of 14 idiopathic patients in each treatment group with gastroduodenal chronic ulcers were treated with omeprazole (20 mg twice daily) combined either with placebo (group A), melatonin (group B) or with Trp (group C). The rate of ulcer healing was determined by gastroduodenoscopy at day 0, 7, 14 and 21 after initiation of therapy. Plasma melatonin, gastrin, ghrelin and leptin were measured by RIA. On day 7, omeprazole by itself (group A) had not healed any ulcers, but four ulcers were healed with omeprazole plus melatonin and two with omeprazole plus tryptophan. At day 21, all ulcers were healed in patients treated with melatonin or Trp, but only 10-12 ulcers were healed in placebo-treated patients. After treatment with omeprazole plus melatonin (group B) or Trp (group C), plasma melatonin levels rose several-fold above initial values. Plasma gastrin level also rose significantly during treatment with omeprazole plus melatonin or Trp, but it was also significantly increased in patients treated with omeprazole plus placebo. Plasma ghrelin levels did not change significantly after treatment with melatonin or Trp, while plasma leptin increased significantly in patients treated with melatonin or Trp but not with placebo. We conclude that melatonin or Trp, when added to omeprazole treatment, accelerates ulcer healing and this likely depends mainly upon the significant increments in plasma melatonin.
Authors:
Krzysztof Celinski; Stanislaw J Konturek; Piotr C Konturek; Thomas Brzozowski; Halina Cichoz-Lach; Maria Slomka; Plonka Malgorzata; Wladyslaw Bielanski; Russel J Reiter
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-1
Journal Detail:
Title:  Journal of pineal research     Volume:  -     ISSN:  1600-079X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8504412     Medline TA:  J Pineal Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Department of Gastroenterology, Medical University, Lublin, Poland Department of Physiology, Jagiellonian University Medical College, Cracow, Poland Department of Internal Medicine, Thueringen-Clinic Saalfeld, Saalfeld, Germany Department of Physiotherapy, University School of Physical Education, Cracow, Poland Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA.
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