Document Detail

Melatonin involvement in immunity and cancer.
MedLine Citation:
PMID:  9641799     Owner:  NLM     Status:  MEDLINE    
The most studied endocrine product of the pineal gland, melatonin, has been reported to be involved in the feedback between neuroendocrine and immune functions and to exert oncostatic action, at least in certain experimental conditions. Melatonin seems to be an integral part of the immune system, by exerting direct and/or indirect stimulatory effects on both cellular and humoral immunity. Likewise, an antitumor activity of melatonin has been shown in several experimental models in vivo and in vitro. The means by which melatonin exerts its effects on immunity and neoplastic growth have not been elucidated. The different putative mechanisms of action of melatonin investigated so far are here briefly discussed.
F Fraschini; G Demartini; D Esposti; F Scaglione
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biological signals and receptors     Volume:  7     ISSN:  1422-4933     ISO Abbreviation:  Biol Signals Recept     Publication Date:    1998 Jan-Feb
Date Detail:
Created Date:  1998-08-20     Completed Date:  1998-08-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9808792     Medline TA:  Biol Signals Recept     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  61-72     Citation Subset:  IM    
Department of Pharmacology, University of Milan, Italy.
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MeSH Terms
Adjuvants, Immunologic / physiology
Immunity / physiology*
Melatonin / pharmacology,  physiology*
Neoplasms / physiopathology*
Tumor Cells, Cultured / drug effects
Reg. No./Substance:
0/Adjuvants, Immunologic; 73-31-4/Melatonin

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