Document Detail


Melatonin inhibits fatty acid transport in inguinal fat pads of hepatoma 7288CTC-bearing and normal Buffalo rats via receptor-mediated signal transduction.
MedLine Citation:
PMID:  11432449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Melatonin inhibits fatty acid uptake and linoleic acid-dependent growth in hepatoma 7288CTC in vivo in Buffalo rats. In this study we measured the effects of melatonin on arteriovenous differences for fatty acids across inguinal fat pads in fed and fasted rats to determine if fatty acid transport in white adipose tissue was also affected by melatonin. Intravenous infusion of melatonin in fasted tumor-bearing rats in vivo simultaneously and rapidly inhibited both fatty acid release from fat pads and fatty acid uptake by the tumors. Perfusion of fat pads in situ in normal rats with melatonin (0.1 nM) inhibited fatty acid release (fasted rats) and uptake (fed rats). Fatty acid transport was restored by addition of any of the following: a melatonin receptor antagonist (S 20928, 1.0 nM), pertussis toxin (0.5 microg/ml), forskolin (1 microM) or 8-Br-cAMP (10 microM). We conclude that fatty acid transport in inguinal fat pads requires cAMP and that melatonin inhibits this transport via a melatonin receptor-mediated, Gi protein-coupled signal transduction pathway. Melatonin has both anticachectic and lipid homeostatic actions in the white adipose tissue of inguinal fat pads.
Authors:
L A Sauer; R T Dauchy; D E Blask
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  68     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-07-02     Completed Date:  2001-07-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2835-44     Citation Subset:  IM    
Affiliation:
Laboratory of Experimental Neuroendocrinology/Oncology, Bassett Research Institute, Cooperstown, NY 13326-1394, USA. lensauer@juno.com
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MeSH Terms
Descriptor/Qualifier:
8-Bromo Cyclic Adenosine Monophosphate / pharmacology
Adipose Tissue / drug effects*,  metabolism
Animals
Biological Transport / drug effects
Circadian Rhythm
Forskolin / pharmacology
Linoleic Acid / metabolism*
Liver Neoplasms, Experimental / metabolism*
Male
Melatonin / pharmacology*
Naphthalenes / pharmacology
Neoplasm Transplantation
Pertussis Toxin
Rats
Rats, Inbred BUF
Rats, Sprague-Dawley
Receptors, Cell Surface / metabolism*
Receptors, Cytoplasmic and Nuclear / metabolism*
Receptors, Melatonin
Signal Transduction / drug effects
Specific Pathogen-Free Organisms
Time Factors
Virulence Factors, Bordetella / pharmacology
Grant Support
ID/Acronym/Agency:
R01 CA76197/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Naphthalenes; 0/Receptors, Cell Surface; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Melatonin; 0/Virulence Factors, Bordetella; 152302-33-5/N-(2-(1-naphthalenyl)ethyl)cyclobutanecarboxamide; 2197-37-7/Linoleic Acid; 23583-48-4/8-Bromo Cyclic Adenosine Monophosphate; 66428-89-5/Forskolin; 73-31-4/Melatonin; EC 2.4.2.31/Pertussis Toxin

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