| Melatonin in septic shock: some recent concepts. | |
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MedLine Citation:
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PMID: 20435434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Melatonin is a versatile molecule, synthesized not only in the pineal gland, but also in many other organs. Melatonin plays an important physiologic role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control, and regulation of mood. Melatonin has also been reported as effective in combating various bacterial and viral infections. Melatonin is an effective anti-inflammatory agent in various animal models of inflammation and sepsis, and its anti-inflammatory action has been attributed to inhibition of nitric oxide synthase with consequent reduction of peroxynitrite formation, to the stimulation of various antioxidant enzymes thus contributing to enhance the antioxidant defense, and to protective effects on mitochondrial function and in preventing apoptosis. In a number of animal models of septic shock, as well as in patients with septic disease, melatonin reportedly exerts beneficial effects to arrest cellular damage and multiorgan failure. The significance of these actions in septic shock and its potential usefulness in the treatment of multiorgan failure are discussed. |
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Authors:
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Venkataramanujan Srinivasan; Seithikurippu R Pandi-Perumal; D Warren Spence; Hisanori Kato; Daniel P Cardinali |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of critical care Volume: 25 ISSN: 1557-8615 ISO Abbreviation: J Crit Care Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-26 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610642 Medline TA: J Crit Care Country: United States |
Other Details:
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Languages: eng Pagination: 656.e1-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Sri Sathya Sai Medical Educational and Research Foundation, Prsanthi Nilayam, Plot-40 Kovai Thirunagar, Coimbatore 641014, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / therapeutic use* Apoptosis / drug effects Disease Models, Animal Humans Inflammation / prevention & control Melatonin / therapeutic use* Mice Multiple Organ Failure / drug therapy Sepsis / prevention & control Shock, Septic / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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