| Melatonin and human reproduction: shedding light on the darkness hormone. | |
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MedLine Citation:
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PMID: 19905996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Melatonin, N-acetyl-5-methoxytryptamine, is a molecule with diverse physiological functions. This neuro-hormone affects reproductive performance in a wide variety of species. In most animals, but not exclusively all, melatonin has an antigonadotrophic effect. The seasonal changes in the number of hours per day that melatonin is secreted mediate the temporal coupling of reproductive activity to seasonal changes in day-length. These observations stimulated a search for a role for the pineal gland and melatonin in human reproduction. Clinical experience related to this issue has yielded inconclusive and sometimes conflicting results. This article reviews the current available evidence concerning the effects of melatonin on human reproductive processes (e.g., puberty, ovulation, pregnancy, and fertility). Possible reasons for the vagueness and elusiveness of the clinical effects are discussed. |
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Authors:
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Venkatramanujam Srinivasan; Warren D Spence; Seithikurippu R Pandi-Perumal; Rahima Zakharia; Kunwar P Bhatnagar; Amnon Brzezinski |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 25 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-12 Completed Date: 2010-01-26 Revised Date: 2010-04-13 |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 779-85 Citation Subset: IM |
Affiliation:
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Sri Sathya Sai Medical Educational and Research Foundation, Prasanthi Nilayam, Coimbatore 641014, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Circadian Rhythm
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physiology Female Humans Male Melatonin / physiology* Ovary / physiology Pineal Gland / physiology Pregnancy Reproduction / physiology* Testis / physiology |
| Chemical | |
Reg. No./Substance:
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73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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