| Melatonin formation in mammals: in vivo perspectives. | |
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MedLine Citation:
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PMID: 20024626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Melatonin is a hormone secreted from the pineal gland specifically at night and contributes to a wide array of physiological functions in mammals. Melatonin is one of the most well understood output of the circadian clock located in the suprachiasmatic nucleus. Melatonin synthesis is controlled distally via the circadian clock located in the suprachiasmatic nucleus and proximally regulated by norepinephrine released in response to the circadian clock signals. To understand melatonin synthesis in vivo, we have performed microdialysis analysis of the pineal gland, which monitors melatonin as well as the precursor (serotonin) and intermediate (N-acetylserotonin) of melatonin synthesis in freely moving animals in realtime at high resolution. Our data revealed a number of novel features of melatonin production undetected using conventional techniques, which include (1) large inter-individual variations of melatonin onset timing; (2) circadian regulation of serotonin synthesis and secretion in the pineal gland; and (3) a revised view on the rate-limiting step of melatonin formation in vivo. This article will summarize the main findings from our laboratory regarding melatonin formation in mammals. |
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Authors:
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Asamanja Chattoraj; Tiecheng Liu; Liang Samantha Zhang; Zheping Huang; Jimo Borjigin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Reviews in endocrine & metabolic disorders Volume: 10 ISSN: 1573-2606 ISO Abbreviation: Rev Endocr Metab Disord Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-03-12 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 100940588 Medline TA: Rev Endocr Metab Disord Country: United States |
Other Details:
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Languages: eng Pagination: 237-43 Citation Subset: IM |
Affiliation:
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Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1301 E., Ann Arbor, MI 48109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arylalkylamine N-Acetyltransferase / chemistry, genetics, metabolism Circadian Rhythm / physiology Humans Mammals / metabolism* Melatonin / biosynthesis*, metabolism Pineal Gland / metabolism Serotonin / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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NS057583/NS/NINDS NIH HHS; R01 NS057583-03/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; 73-31-4/Melatonin; EC 2.3.1.87/Arylalkylamine N-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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