Document Detail

Melatonin excretion in normal children and in tuberous sclerosis complex with sleep disorder responsive to melatonin.
MedLine Citation:
PMID:  15791917     Owner:  NLM     Status:  MEDLINE    
To determine normal melatonin excretion patterns in healthy children without sleep disorder and to compare these with those of patients with tuberous sclerosis complex and sleep disorder responsive to exogenous melatonin, we measured 6-sulfatoxymelatonin excretion in 21 healthy children and in 7 patients with tuberous sclerosis complex and sleep disorder responsive to melatonin (a 5 mg oral dose increasing total sleep time). Total excretion, cosinor percentage, and acrophase time of 6-sulfatoxymelatonin excretion were estimated. In normal children, total 6-sulfatoxymelatonin excretion was range 11.1 to 40.2 microg (mean 19.0 microg, SD 7.4 microg); cosinor percentage rhythm range was 52.9% to 100% (mean 87%, median 94%); and acrophase time range was 23 hours, 54 minutes to 10 hours, 42 minutes (mean 5 hours, 54 minutes; median 4 hours, 12 minutes). Fifth and 95th percentiles were 11.1 to 29.0 microg, 57.8% to 99.9%, and 2 hours, 1 minute to 10 hours, 4 minutes. In tuberous sclerosis, normal patterns of melatonin excretion were seen in responders. Circadian patterns of melatonin excretion were similar in children and adults. We propose that exogenous melatonin can act by a simple sedative action.
Eleanor Hancock; Finbar O'Callaghan; Judie English; John P Osborne
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of child neurology     Volume:  20     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-03-28     Completed Date:  2005-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  21-5     Citation Subset:  IM    
Department of Paediatrics, Royal United Hospital Bath NHS Trust, School of Health, University of Bath, Bath, UK.
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MeSH Terms
Administration, Oral
Antioxidants / administration & dosage,  pharmacokinetics*
Case-Control Studies
Child, Preschool
Circadian Rhythm*
Melatonin / administration & dosage,  analogs & derivatives*,  pharmacokinetics*,  urine
Reference Values
Sleep Disorders / complications*,  physiopathology
Tuberous Sclerosis / complications*,  physiopathology
Reg. No./Substance:
0/Antioxidants; 2208-40-4/6-sulfatoxymelatonin; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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