| Melatonin-estrogen interactions in breast cancer. | |
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MedLine Citation:
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PMID: 15813897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this article, we review the experimental data supporting an oncostatic role of melatonin on hormone-dependent mammary tumors. Beginning with the evidence on the role of estrogens in breast cancer etiology and mammary tumor growth, we summarize the actual therapeutic strategies with estrogens as a target. Additionally, we demonstrate that melatonin fulfills all the requirements to be considered as an antiestrogenic drug which shares properties with drugs of the two main pharmacological groups of substances which interact with the estrogen-signaling pathways such as: (i) drugs that act through the estrogen receptor interfering with the effects of endogenous estrogens; and (ii) drugs that interfere with the synthesis of estrogens by inhibiting the enzymes controlling the interconversion from their androgenic precursors. Furthermore, melatonin decreases circulating levels of estradiol. These three antiestrogenic mechanisms suggest that melatonin may have an important role in the prevention and treatment of hormone-dependent mammary cancer. |
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Authors:
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Emilio J Sánchez-Barceló; Samuel Cos; Dolores Mediavilla; Carlos Martínez-Campa; Alicia González; Carolina Alonso-González |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of pineal research Volume: 38 ISSN: 0742-3098 ISO Abbreviation: J. Pineal Res. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-07 Completed Date: 2005-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8504412 Medline TA: J Pineal Res Country: Denmark |
Other Details:
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Languages: eng Pagination: 217-22 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, School of Medicine, University of Cantabria, Santander, Spain. barcelo@unican.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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physiopathology* Estrogens / physiology* Female Humans Melatonin / physiology* Selective Estrogen Receptor Modulators |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Selective Estrogen Receptor Modulators; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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