| Melatonin enhances the in vitro and in vivo repair of severed rat sciatic axons. | |
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MedLine Citation:
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PMID: 15698928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examines the effects of several experimental compounds [melatonin (MEL), cyclosporin A (CsA), glial-derived neurotrophic factor (GDNF), and methylprednisolone (MP)] on polyethylene glycol (PEG)-induced repair in vitro and/or in vivo by plasmalemmal fusion (PEG-fusion) of sciatic axons severed by crushing. As measured by conduction of compound action potentials (CAPs) through the lesion site, a significantly (p<0.025) higher percentage (75%) of crushed rat sciatic axons can be repaired in vitro by PEG-fusion following exposure to MEL compared to PEG-fusion of severed sciatic axons in control Krebs saline that contains calcium (CTL=20%). In contrast, no other experimental compound (GDNF: 45%; MP: 42%; CsA: 24%) produces a significant improvement in PEG-fusion success compared to CTL. Further, MEL produces significantly (p<0.001) larger peak CAP amplitudes conducted through the lesion site following PEG-fusion compared to CTL or any other experimental compound in vitro. Additionally, MEL significantly (p<0.025) increases the ability to PEG-fuse sciatic axons in vivo, compared to CTL. Finally, PEG-fusion success in vivo is significantly (p<0.01) greater in calcium-free CTL (CTL-Ca) compared to CTL. |
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Authors:
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Ronda C Stavisky; Joshua M Britt; Aleksej Zuzek; Elizabeth Truong; George D Bittner |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2004-12-15 |
Journal Detail:
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Title: Neuroscience letters Volume: 376 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-02-08 Completed Date: 2005-04-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 98-101 Citation Subset: IM |
Affiliation:
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Section of Neurobiology, The University of Texas at Austin, 1 University Station 0C0920, Austin, TX, 78712-0248, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Calcium / metabolism Culture Media / chemistry Cyclosporine / pharmacology Electrophysiology Enzyme Inhibitors / pharmacology Melatonin / pharmacology* Methylprednisolone / pharmacology Nerve Crush Nerve Regeneration / drug effects* Neuroprotective Agents / pharmacology* Organ Culture Techniques Polyethylene Glycols / pharmacology Rats Rats, Sprague-Dawley Sciatic Nerve / drug effects*, pathology Surface-Active Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Enzyme Inhibitors; 0/Neuroprotective Agents; 0/Polyethylene Glycols; 0/Surface-Active Agents; 59865-13-3/Cyclosporine; 73-31-4/Melatonin; 7440-70-2/Calcium; 83-43-2/Methylprednisolone |
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