Document Detail


Melatonin delays photoreceptor degeneration in the rds/rds mouse.
MedLine Citation:
PMID:  11303736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Photoreceptors in retinitis pigmentosa (RP), a group of inherited retinal degenerative diseases, die through apoptosis. Since melatonin protects against neuronal apoptotic death, we tested its ability to slow photoreceptor degeneration in the rds/rds mouse, an animal model for RP. Shortly after birth, rds/rds mice were given daily i.p. injections of melatonin or vehicle for 11 weeks. Melatonin treatment significantly delayed photoreceptor loss and reduced the number of apoptotic photoreceptors. Further studies should determine if melatonin will have potential for the treatment of certain human retinal degenerations.
Authors:
F Q Liang; T S Aleman; ZaixinYang; A V Cideciyan; S G Jacobson; J Bennett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroreport     Volume:  12     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-16     Completed Date:  2001-08-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  1011-4     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Cell Count
Cell Nucleus / drug effects
Electroretinography
In Situ Nick-End Labeling
Melatonin / pharmacology*
Mice
Mice, Inbred Strains
Photoreceptor Cells / drug effects,  pathology*
Retinal Degeneration / genetics,  pathology*
Retinitis Pigmentosa / genetics,  pathology*
Grant Support
ID/Acronym/Agency:
DK07748/DK/NIDDK NIH HHS; EY 12156/EY/NEI NIH HHS; R01 EY10820/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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