| Melatonin deficiency and fibrous dysplasia: might a relation exist? | |
| | |
MedLine Citation:
|
PMID: 12376077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fibrous dysplasia of bone might be monostotic, polystotic, or occurs as a part of McCune-Albright syndrome and Jaffe-Lichtenstein syndrome. Activating mutations of GNAS1 gene was identified in patients with fibrous dysplasia. However, fibrous dysplasia might occur in the absence of these mutations and fibrous dysplastic tissue was produced in vitro by the effects of excess exogenous cAMP on human osteogenic cells. It was proved that the fibrous dysplastic tissue is deficient in bone sialoprotein. Melatonin deficiency might be hypothesized in syndromes associated with fibrous dysplasia or formation of fibrous dysplasia-like tissue. The receptor RZR/ROR is the nuclear receptor of melatonin and the human bone sialoprotein gene contains a RZR/ROR response element. It was supposed that binding of melatonin to its membrane receptors results in changes in the levels of activity of nuclear cAMP that lead to alteration of expression of bone sialoprotein. Also, melatonin deficiency might increase cAMP in bone through its effect on prostaglandins of the E group. Further, melatonin deficiency might explain precocious puberty in cases of McCune-Albright syndrome. We might hypothesize that melatonin deficiency might play a role in development of fibrous dysplasia in some cases. |
| | |
Authors:
|
M E Abdel-Wanis; H Tsuchiya |
Related Documents
:
|
3293247 - Surgical approach in severe cases of maxillonasal dysplasia (binder's syndrome). 2334367 - Inherited epidermal dysplasia in holstein-friesian calves. 19100937 - Anesthetic implications of ellis-van creveld syndrome. 20329417 - Ellis van creveld syndome. 15712197 - Hypothelia, syndactyly, and ear malformation--a variant of the scalp-ear-nipple syndrom... 3841917 - Pseudoclaudication in lumbar disc protrusions. contribution in understanding the etio-p... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Medical hypotheses Volume: 59 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2002 Nov |
Date Detail:
|
Created Date: 2002-10-11 Completed Date: 2003-06-30 Revised Date: 2010-02-04 |
Medline Journal Info:
|
Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: Scotland |
Other Details:
|
Languages: eng Pagination: 552-4 Citation Subset: IM |
Affiliation:
|
Orthopaedic Department, Faculty of Medicine, Kanazawa University, Kanazawa, Japan. wanis307@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bone Development
/
physiology Cyclic AMP / physiology Fibrous Dysplasia of Bone / etiology*, genetics GTP-Binding Protein alpha Subunits, Gs / deficiency, genetics Humans Melatonin / deficiency*, physiology Models, Biological Receptors, Cell Surface / genetics, metabolism Receptors, Cytoplasmic and Nuclear / genetics, metabolism Receptors, Melatonin Second Messenger Systems / physiology Sialoglycoproteins / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Cell Surface; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Melatonin; 0/Sialoglycoproteins; 0/integrin-binding sialoprotein; 60-92-4/Cyclic AMP; 73-31-4/Melatonin; EC 3.6.5.1/GTP-Binding Protein alpha Subunits, Gs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Insulin resistance: a metabolic link between depressive disorder and atherosclerotic vascular diseas...
Next Document: Are neuronal activity-associated magnetic fields the physical base for memory?