| Melatonin counteracts oxidative stress in rats fed an ochratoxin A contaminated diet. | |
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MedLine Citation:
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PMID: 15683468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mycotoxin ochratoxin A (OTA) is a widespread contaminant in human and animal food products. It induces a wide range of toxic effects including lipid peroxidation through the generation of free radicals. The aim of this work was to evaluate the antioxidant effects of melatonin against OTA-induced oxidative stress in liver and kidney in rats. Treated animals were fed OTA-contaminated diet (3 mg/kg) for 15 days before, during and after melatonin administration (20 mg/kg bw). The results indicate that OTA caused severe effects typical to those reported in the literature for ochratoxicosis. Melatonin alone was effective in the improving food intake, body weight gain, serum total protein, albumin, the activities of alkaline phosphatase, G-glutamyl transferase and creatinine kinase and liver and kidney glutathione peroxidase, superoxide dismutase and malondialdehyde. Rats fed OTA-contaminated diet before, during or after melatonin administration showed a significant improvement in all tested parameters toward the normal values of the controls. This improvement was most pronounced in the group pretreated with melatonin. It is concluded that melatonin exhibits a preventive effect against OTA-induced oxidative stress through its role in the scavenging of free radicals and/or the prevention of lipid peroxidation. |
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Authors:
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Mosaad A Abdel-Wahhab; Mona M Abdel-Galil; Mohey El-Lithey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pineal research Volume: 38 ISSN: 0742-3098 ISO Abbreviation: J. Pineal Res. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-02-01 Completed Date: 2005-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8504412 Medline TA: J Pineal Res Country: Denmark |
Other Details:
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Languages: eng Pagination: 130-5 Citation Subset: IM |
Affiliation:
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Department of Food Toxicology and Contaminants, National Research Center, Cairo, Egypt. mosaad_attia@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Glutathione Peroxidase / metabolism Kidney / drug effects, metabolism Liver / drug effects, metabolism Male Malondialdehyde / metabolism Melatonin / pharmacology* Mycotoxins / pharmacology* Ochratoxins / pharmacology* Oxidative Stress / drug effects* Rats Rats, Sprague-Dawley Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Mycotoxins; 0/Ochratoxins; 303-47-9/ochratoxin A; 542-78-9/Malondialdehyde; 73-31-4/Melatonin; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
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