Document Detail

Melatonin and clock genes expression in the cardiovascular system .
MedLine Citation:
PMID:  23277083     Owner:  NLM     Status:  In-Data-Review    
Generation of circadian oscillations is based on rhythmic expression of clock genes and subsequent post-transcriptional and post-translational modifications. In addition to the central circadian oscillator - the suprachiasmatic nucleus (SCN), peripheral oscillators have been demonstrated in many tissues, including the heart and blood vessels. Melatonin mediates cyclic lighting conditions to rhythmic endocrine signal and is able to synchronize neuronal firing in the SCN via membrane receptors. Clock gene expression is melatonin sensitive in the pars tuberalis, genes cry1 and tim1 respond to single injection while neurod1 and npas4 are influenced via long lasting mechanisms. In the rat heart, melatonin phase advanced expression of per2 and bmal1 independently from its effects on the SCN. Melatonin is an important endogenous signal able to synchronize circadian oscillations in the cardiovascular system. It may be effective especially in situations when the circadian control is weakened or organism must adapt to rapid changes in rhythmic environmental conditions.
Michal Zeman; Iveta Herichova
Related Documents :
8274753 - Expression of platelet-derived growth factor and its receptors by two pre-b acute lymph...
12210033 - Analysis of gene expression in egr-1 transfected human fibrosarcoma cells.
8628243 - The bacterial phleomycin resistance gene ble as a dominant selectable marker in chlamyd...
Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  5     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  743-53     Citation Subset:  IM    
Department of Animal Physiology and Ethology, Comenius University Bratislava, Mlynska dolina B-2, 842 15 Bratislava, Slovak Republic.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Assessing limb apraxia in traumatic brain injury and spinal cord injury.
Next Document:  Causes and consequences of low grade endotoxemia and inflammatory diseases .