Document Detail

Melatonin attenuates L-cysteine-induced seizures and lipid peroxidation in the brain of mice.
MedLine Citation:
PMID:  8912236     Owner:  NLM     Status:  MEDLINE    
The effect of melatonin, a potent free radical scavenger, on L-cysteine-induced seizures and lipid peroxidation was investigated in mice. When L-cysteine (1.25, or 5.0 mumol/animal) was injected intracerebroventricularly (i.c.v.) into mice, severe tonic seizures were observed for over 20 sec in 75% and 100% of the treated mice, respectively. However, when melatonin (20 or 100 mg/kg) was injected subcutaneously (sc) into mice 15 min before L-cysteine injection (1.25 mumol/animal, i.c.v.), the incidence of seizures was observed in only 35% and 20% of the treated mice, respectively. Furthermore, when L-cysteine (1.25 or 5.0 mumol/animal, i.c.v.) was injected into mice, lipid peroxidation in whole brain 20 min after injection was significantly increased by 56% or 67% as compared to that of the control. However, when the seizures induced by L-cysteine (1.25 mumol/animal) were abolished by preadministration of melatonin, the increased lipid peroxidation induced by L-cysteine was prevented. These results suggest that there may be a positive correlation between free radical formation and seizures induced by L-cysteine and that melatonin affords protection against the seizures as well as against the associated lipid peroxidation.
H Yamamoto; H Tang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pineal research     Volume:  21     ISSN:  0742-3098     ISO Abbreviation:  J. Pineal Res.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-02-10     Completed Date:  1997-02-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8504412     Medline TA:  J Pineal Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  108-13     Citation Subset:  IM    
Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan.
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MeSH Terms
Brain / drug effects*,  metabolism
Cystine / toxicity*
Free Radical Scavengers / pharmacology*
Injections, Intraventricular
Injections, Subcutaneous
Lipid Metabolism
Lipid Peroxidation / drug effects*
Malondialdehyde / metabolism
Melatonin / pharmacology*
Seizures / chemically induced,  prevention & control*
Reg. No./Substance:
0/Free Radical Scavengers; 542-78-9/Malondialdehyde; 56-89-3/Cystine; 73-31-4/Melatonin

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