Document Detail


Melatonin Responsive Hemicrania Continua in Which Indomethacin Was Associated With Contralateral Headache.
MedLine Citation:
PMID:  24261314     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Headache is a well-documented side effect of indomethacin in the older medical literature; however, it has rarely been commented on in indomethacin-responsive hemicrania continua. We describe the case of a 60-year-old woman with left-sided hemicrania continua whose indomethacin treatment was associated with a continuous right-sided migraine. Her indomethacin therapy was discontinued heralding a return of her left-sided hemicrania continua and a resolution of her right-sided migraine. Her hemicrania continua then responded well to melatonin, with recurrence on stopping and improvement on restarting. This is the most detailed description of headache as a side effect of indomethacin in a headache patient we are aware of, and one of only a few reported cases of melatonin-responsive hemicrania continua. We review the evidence of headache as a side effect of indomethacin in order to highlight its importance in the treatment of headache disorders. We emphasize that indomethacin headache response may be more than simply a beneficial or neutral one and might be relevant to some cases of apparently indomethacin-resistant hemicrania continua. We hope this case may encourage clinicians to inquire about headache as a potential side effect of indomethacin.
Authors:
Milo Hollingworth; Tim M Young
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-21
Journal Detail:
Title:  Headache     Volume:  -     ISSN:  1526-4610     ISO Abbreviation:  Headache     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 American Headache Society.
Affiliation:
University College London Medical School, London, UK.
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