| Melatonin induces follicle maturation in Danio rerio. | |
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MedLine Citation:
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PMID: 21647435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most organisms modulate their reproductive activity responding to day length by the nocturnal release of melatonin by the pineal gland. This hormone is also responsible for synchronizing reproduction with specific external environment stimuli in order to optimize reproductive success.The aim of this study was to establish the effect of melatonin on zebrafish reproduction.Adult females were daily exposed, via water, to two different doses (100 nM and 1 µM) of melatonin. Melatonin led to an increase of the Gonado Somatic Index (GSI) associated with the increase of eggs production, and the raise of gene and protein levels of vitellogenin (VTG) and estradiol receptor α (ERα) in the liver. The ability of melatonin to increase fecundity was consistent with a significant increase of gene transcription of kiss 1, kiss 2, gnrh3, in the brain, and lh in the pituitary, while in the ovary (in class IIIB follicles), with a significant decrease of two genes codifying for intra-ovarian regulators of premature oocyte maturation, the tgfβ1 and the bmp15. The reduction in the expression of these two genes was concomitant with the increase of lhr and a modulation of mprα and mprβ gene transcription, whose proteins are involved in oocyte maturation. Melatonin also exerted a direct action on follicles as shown by the increase of the oocytes undergoing to germinal vesicle break down (GVBD) and modulated mpr α and β gene expression in the in vitro exposure.These data highlight the effects of melatonin in promoting zebrafish reproduction exerting its effects either in the brain-pituitary and in the gonads. |
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Authors:
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Oliana Carnevali; Giorgia Gioacchini; Francesca Maradonna; Ike Olivotto; Beatrice Migliarini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-05-25 |
Journal Detail:
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Title: PloS one Volume: 6 ISSN: 1932-6203 ISO Abbreviation: PLoS ONE Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-07 Completed Date: 2011-09-22 Revised Date: 2013-05-24 |
Medline Journal Info:
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Nlm Unique ID: 101285081 Medline TA: PLoS One Country: United States |
Other Details:
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Languages: eng Pagination: e19978 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze del Mare, Università Politecnica delle Marche, Ancona, Italy. o.carnevali@univpm.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, physiology Female Fertility / drug effects Melatonin / pharmacology* Ovarian Follicle / drug effects*, growth & development* Pituitary Gland / physiology Reproduction / drug effects Zebrafish / growth & development*, physiology |
| Chemical | |
Reg. No./Substance:
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73-31-4/Melatonin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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